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Search Results for " aryl hydrocarbon receptor "

50

抑制剂 & 化合物

13

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7202	ITE	AhR; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism
	ITE 是一种有效的芳烃受体 (AhR) 内源性激动剂，Ki 值为 3 nM。它具有免疫抑制作用。
T21966	MeBIO	GSK-3; Aryl Hydrocarbon Receptor; CDK	Cell Cycle/Checkpoint; Immunology/Inflammation; PI3K/Akt/mTOR signaling; Stem Cells
	MeBIO 是一种芳烃受体激动剂，对 GSK-3 和 CDK1/CyclinB 的 IC50 分别为 44 和 55 μM。 MeBIO 不影响 GSK-3β。
T1960	YL-109	AhR; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism
	YL-109是一种抗肿瘤剂，可以通过芳烃受体 AhR 信号传导诱导 Hsp70 相互作用蛋白 (CHIP) 表达，具有抑制乳腺癌细胞生长和侵袭性的能力。
T20625	Prochloraz 咪鲜胺,Sporgon,Prelude	Estrogen Receptor/ERR; AhR; Androgen Receptor; Antifungal	Endocrinology/Hormones; Immunology/Inflammation; Metabolism; Microbiology/Virology
	Prochloraz (Prelude) 是咪唑类抗真菌剂。Prochloraz 抑制羊毛甾醇的细胞色素 P450 依赖性 14α-脱甲基作用，由此抑制麦角固醇的生物合成，从而导致真菌细胞膜破裂和细胞死亡。它也是雌激素受体和雄激素受体的拮抗剂，IC50分别为25 μM 和4 μM，并激活芳烃受体，EC50为1μM。
T5622	BAY-218 AHR antagonist 1	AhR; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism
	BAY-218 (AHR antagonist 1) 是一种芳基烃受体(AHR)拮抗剂，在人细胞系中的IC50值为 39.9 nM。
T4608	PDM2	AhR; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism
	PDM2 是一种有效的选择性芳烃受体 (AhR) 拮抗剂，Ki 为 1.2±0.4 nM。
T15410	GNF351	Aryl Hydrocarbon Receptor	Immunology/Inflammation
	GNF351 是芳烃受体 (AhR) 的完全拮抗剂，具有抑制 DRE 依赖性和非依赖性活性的能力。它与结合到 AhR 的光亲和性 AhR 配体竞争，IC50为 62 nM。它在小鼠或人角质形成细胞中的毒性极小。
T10007	1,4-Chrysenequinone Chrysene-1,4-dione,1,4-屈醌	AhR	Immunology/Inflammation; Metabolism
	1,4-Chrysenequinone (Chrysene-1,4-dione) 是多环芳香烃类，是芳烃受体 (AhR) 的激活剂
T10270	BAY 2416964	Aryl Hydrocarbon Receptor	Immunology/Inflammation
	BAY 2416964 是一种可口服的芳基烃受体拮抗剂，IC50为 341 nM，可用于研究实体瘤。
T2448	CH-223191 CH 223191	AhR; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism
	CH-223191 是一种特异性有效的芳烃受体 (AhR) 拮抗剂，可抑制 TCDD 介导的核转位和 AhR 的 DNA 结合，抑制 TCDD 诱导的荧光素酶活性的 IC50值为 0.03 μM。
T4607	CAY 10465 CAY10465,CAY10465 Exclusive	AhR; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism
	CAY 10465 是一种选择性和高亲和力的芳香烃受体(AhR)激动剂，Ki 值为 0.2 nM。
TQ0257	FICZ 6-Formylindolo[3,2-b]carbazole	Aryl Hydrocarbon Receptor	Immunology/Inflammation
	FICZ (6-Formylindolo[3,2-b]carbazole) 是芳烃受体 (AhR) 的有效芳基激动剂，Kd 值为70 pM。
T1831	StemRegenin 1 SR1	AhR; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism
	StemRegenin 1 (SR1) 是一种芳香烃受体拮抗剂，IC50为 127 nM。
T21704	5-fluoro 203 5F-203,NSC-703786	Others	Others
	5-fluoro 203 (NSC-703786) 是一种细胞毒性分子。它可激活芳香烃受体(AhR) 信号传导，诱导 CYP1A1 的转录，从而形成 DNA 加合物以及细胞周期阻滞。它可以提高活性氧水平，并激活 ERK、p38以及JNK。
T13276	VAF347 4-(3-氯苯基)-N-[4-(三氟甲基)苯基]嘧啶-2-胺	Aryl Hydrocarbon Receptor	Immunology/Inflammation
	VAF347 是细胞可渗透且高度亲和力的芳烃受体激动剂，可诱导AhR 信号传导，具有抗炎作用。它抑制颗粒单核细胞 (GM 期) 前体中 CD14+CD11b+单核细胞的发育。
T2623	PD98059 PD 98059	ERK; Aryl Hydrocarbon Receptor; MEK; Autophagy	Autophagy; Immunology/Inflammation; MAPK
	PD98059 是一种 MEK 抑制剂，抑制 MEK1 和 MEK2 (IC50=2/50 μM)，具有非 ATP 竞争性。PD98059 也是一种 AHR 的配体而起拮抗作用。PD98059 可以抑制细胞自噬。
T4644	Tapinarof GSK2894512,Benvitimod,苯烯莫德,WBI 1001	AhR; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism
	Tapinarof (Benvitimod) 是一种从发光杆菌中提取的天然产物，可消除炎症。它是芳烃受体 (AhR) 激动剂，EC50为 13 nM。
T2148	Carbidopa monohydrate Carbidopa Hydrate,S(-)-Carbidopa,卡比多巴水合物	Decarboxylase; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism; Others
	Carbidopa monohydrate (S(-)-Carbidopa) 是一种外周型脱羧酶抑制剂，可用于帕金森病的研究。它是一种选择性芳香烃受体 (AhR) 调节剂。它抑制胰腺癌细胞和肿瘤生长。
T0640	Benzyl butyl phthalate BBP,邻苯二甲酸丁苄酯,1,2-benzenedicarboxylic acid,butyl phenylmethyl ester,Butyl benzyl phthalate	Others; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Others
	Benzyl butyl phthalate (1,2-benzenedicarboxylic acid) 是邻苯二甲酸酯的一员，可激活乳腺癌细胞中的芳香烃受体，刺激 SPHK1/S1P/S1PR3 信号传导，促进转移性乳腺癌干细胞的形成。它通过上调 Zeb1 的表达，可引起血管瘤细胞的迁移和侵袭。
T2707	Pifithrin-α hydrobromide Pifithrin hydrobromide,Pifithrin-α (PFTα) HBr,Pifithrin-α,PFTα,PFTα hydrobromide	Ferroptosis; Aryl Hydrocarbon Receptor; p53	Apoptosis; Immunology/Inflammation
	Pifithrin-α hydrobromide (Pifithrin-α hydrobromide) 是一种 p53 抑制剂，可抑制 p53 反应基因的 p53 依赖性反式激活。它也是芳烃受体的激动剂。
T8980	SGA360	Aryl Hydrocarbon Receptor	Immunology/Inflammation
	SGA360 是选择性芳烃 (Ah) 受体调节剂。它具有抗炎特性。
T10269	AHR antagonist 2	Aryl Hydrocarbon Receptor	Immunology/Inflammation
	AHR antagonist 2 是芳基烃受体的拮抗剂。人 AHR 和小鼠 AHR 的 IC50 分别为 0.885 和 2.03 nM。
T5541	PDM11 1-[2-(4-Chloro-phenyl)-vinyl]-3,5-diMeth,PDM 11	AhR	Immunology/Inflammation; Metabolism
	PDM11 (1-[2-(4-Chloro-phenyl)-vinyl]-3,5-diMeth) 是抗氧化剂白藜芦醇的衍生物。它在白藜芦醇活性测定中不活跃。它对辐射分解产生的羟基自由基引发的亚油酸胶束氧化没有明显的保护作用。
T10325	ANI-7	Chk	Cell Cycle/Checkpoint
	ANI-7是芳香烃受体（AhR）途径的激活剂。ANI-7抑制多种癌症细胞的生长，并有效且选择性地抑制MCF-7乳腺癌症细胞的生长（GI50:0.56μM）。
T3637	Pifithrin-β hydrobromide Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide)	Ferroptosis; p53	Apoptosis
	Pifithrin-β hydrobromide (Cyclic PFT-α) 是一种 p53 的抑制剂，可逆地阻断 p53 依赖性转录激活和细胞凋亡。IC50值为23 μM。
T10526	β-NF-JQ1	Others	Others
	β-NF-JQ1是一种PROTAC，可将芳烃受体E3 （AhR E3）连接酶招募到目标蛋白上。β-NF-JQ1使用β-NF 作为AhR 配体靶向含溴odomain（BRD）的蛋白，诱导AhR 和BRD 蛋白相互作用。β-NF-JQ1显示出与蛋白敲除活性相关的强大的抗癌活性。
T20307	Benzyl 2-naphthyl ether AI3 00945,AI300945,AI3-00945
	Benzyl 2-naphthyl ether causes the activation of the aryl hydrocarbon receptor.
T24960	10-Cl-BBQ 10ClBBQ
	10-Cl-BBQ is a ligand of aryl hydrocarbon receptor (AhR).
T23686	AHR-activator-1023 Branching Morphogenesis Modulator 1023,Cpd 1023,Compound 1023,BMM 1023
	AHR-activator-1023 is the aryl hydrocarbon receptor activator. It is also a specific FGF2-induced branching morphogenesis modulator.
T25235	CHD-5 CHD5
	CHD-5 is a selective antagonist of the aryl hydrocarbon receptor (AhR).
T10258	AFP464 free base NSC710464 free base	HIF	Angiogenesis; Chromatin/Epigenetic
	AFP464 (NSC710464) free base is an active HIF-1α inhibitor (IC50: 0.25 μM) and a potent aryl hydrocarbon receptor (AhR) activator.
T22528	6,2',4'-Trimethoxyflavone	Others	Others
	The compound is an Aryl hydrocarbon receptor antagonist (EC50 = 0.9 μM). It also has no short term agonist activity and no species or promoter dependence.
T16082	Mivotilate YH439	Others	Others
	Mivotilate, a potent, non-toxic aryl hydrocarbon receptor (AhR) activator, functions as a hepatoprotective agent.
T10271	AHR antagonist 4	Others	Others
	AHR antagonist 4 is a potent aryl hydrocarbon receptor (AHR) antagonist(example 293; IC50: 82.2 nM).It has anti-cancer effects.
T10272	AHR antagonist 5	Others	Others
	AHR antagonist 5 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist(example 39; IC50 < 0.5 μΜ). It significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1.
T71938	MNF
	MNF, also known as 3,4-MNF, is an antagonist of the aryl hydrocarbon receptor (AhR). MNF reduces UVR-mediated immunosuppression and induces Tregs in murine contact hypersensitivity (CHS).
T22725	DiMNF	Others	Others
	DiMNF is a selective aryl hydrocarbon receptor (AHR) modulator. It also suppresses the expression of CD55 and CD46 induced by IL-1β in an inflammatory tumor cell microenvironment.
T23400	StemRegenin 1 (hydrochloride) StemRegenin 1 (hydrochloride) (1227633-49-9 free base)	Others	Others
	StemRegenin 1 is an aryl hydrocarbon receptor signaling antagonist (IC50: 127 nM in CD34+ cells).
T10273	AhR modulator-1	Others	Others
	AhR modulator-1 is a selective and orally active aryl hydrocarbon receptor (AhR) modulator. It inhibits metastasis, in part, by inhibiting prostatic VEGF production prior to tumor formation. It also possesses anti-estrogenic properties in rat uterus.
T70257	Avitriptan HCl
	Avitriptan, also known as BMS-180048, is a selective 5-HT1-like receptor agonist. Avitriptan is an effective compound for the treatment of migraine headaches with a prolonged duration of response. Avitriptan Is a Ligand and Agonist of Human Aryl Hydrocarbon Receptor That Induces CYP1A1 in Hepatic and Intestinal Cells.
T72430	L-Kynurenine sulfate
	L-Kynurenine sulfate 是一种芳香烃受体AHR 激动剂，可激活 AHR 导向的初始T 细胞极化至抗炎 Treg 表型。
T61244	AhR agonist 2
	AhR agonist 2 (Compound 12a) is a highly potent agonist of the aryl hydrocarbon receptor (AhR), exhibiting an EC50 value of 0.03 nM. This compound rapidly induces nuclear enrichment of AhR and initiates transcription of downstream genes, thereby promoting skin barrier repair. AhR agonist 2 shows promising potential for psoriasis research [1].
T63389	AHR antagonist 5 hemimaleate
	AHR antagonist 5 hemimaleate 是一种口服具有活力的芳香烃受体 (AHR) 的有效拮抗剂 (IC50< 0.5 μM)。AHR antagonist 5 hemimaleate 联合检测点抑制剂 anti-PD-1 对肿瘤生长表现出抑制作用。
T60539	KG-548
	KG-548 是一种ARNT/TACC3干扰剂以及HIF-1α抑制剂。KG-548 通过 ARNT 的 PAS-B 结构域与 TACC3 竞争性结合，直接干扰ARNT/TACC3复合物的形成。ARNT 是芳基烃受体核转运蛋白，也称为 HIF-β。
T79283	hCYP1B1-IN-1
	hCYP1B1-IN-1 (compound B18)为高效的hCYP1B1抑制剂(IC50=3.6 nM)，同时亦为芳香烃受体拮抗剂。该化合物展现优秀的代谢稳定性与细胞膜渗透性，能有效抑制MCF-7细胞迁移。
T79436	AHR agonist 4	Aryl Hydrocarbon Receptor	Immunology/Inflammation
	AHR agonist 4 (compound 24e) 是针对芳烃受体AHR的激动剂，关联Th17/22与Treg细胞的免疫调节作用。作为治疗银屑病的潜在先导化合物，它能够缓解由咪喹莫特 (IMQ) 诱发的银屑病样皮肤病变。
T78716	MKA031
	MKA031（compound 6y）作为一种非竞争性MIF抑制剂，展现出1.7 μM的IC50。该化合物能够阻断MIF/AIF相互作用、抑制MIF核内转移，并干预MNNG所诱发的细胞死亡。MKA031主要用于研究慢性丙型肝炎病毒感染。
T72056	KYN-101
	KYN-101是一种高效、选择性的芳香烃受体(AHR)合成拮抗剂,在人HepG2 DRE 荧光素酶报告基因检测中IC50为22 nM,在小鼠Hepa1 Cyp-luc 检测中IC50为23 nM。KYN-101逆转IDO/TDO 介导的肿瘤进展,提高PD-1阻断B16 IDO 荷瘤小鼠和表达内源性高水平IDO 的CT26结直肠癌模型的疗效。
T83826	1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin 1,2,3,6,7,8-HxCDD,PCDD 67
	1,2,3,6,7,8-六氯二苯并-p-二噁英是一种多氯代二苯并二噁英（PCDD）。它是芳香烃受体（AhR; EC50s分别为5.4和9.3 nM，在4和8小时的报告检测中）的激动剂。1,2,3,6,7,8-六氯二苯并-p-二噁英（0.5和2 µg/kg）降低了小鼠对羊红血球的抗体产生。在动物饲料和靠近市政废物焚烧炉的空气中均有发现。
T70313	Indoxyl Sulfate-d5 potassium salt
	Indoxyl sulfate-d5 is intended for use as an internal standard for the quantification of indoxyl sulfate by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan. It is formed via sulfation of indole, an intermediate generated from tryptophan by intestinal bacteria, by the sulfotransferase (SULT) isoform 1A1 variant 2 (SULT1A12) in the liver. Indoxyl sulfate activates the aryl* hydrocarbon receptor (AhR) in HepG2 40/6 hepatoma cells (EC50 = 12.1 nM in a reporter assay). ...

化合物

Cat.No: T7202

Target: AhR, Aryl Hydrocarbon Receptor

Cat.No: T21966

Target: GSK-3, Aryl Hydrocarbon Receptor, CDK

Cat.No: T1960

Target: AhR, Aryl Hydrocarbon Receptor

Cat.No: T20625

Synonym: 咪鲜胺,Sporgon,Prelude

Target: Estrogen Receptor/ERR, AhR, Androgen Receptor, Antifungal

Cat.No: T5622

Synonym: AHR antagonist 1

Target: AhR, Aryl Hydrocarbon Receptor

Cat.No: T4608

Target: AhR, Aryl Hydrocarbon Receptor

Cat.No: T15410

Target: Aryl Hydrocarbon Receptor

1,4-Chrysenequinone

Cat.No: T10007

Synonym: Chrysene-1,4-dione,1,4-屈醌

Target: AhR

Cat.No: T10270

Target: Aryl Hydrocarbon Receptor

Cat.No: T2448

Synonym: CH 223191

Target: AhR, Aryl Hydrocarbon Receptor

Cat.No: T4607

Synonym: CAY10465,CAY10465 Exclusive

Target: AhR, Aryl Hydrocarbon Receptor

Cat.No: TQ0257

Synonym: 6-Formylindolo[3,2-b]carbazole

Target: Aryl Hydrocarbon Receptor

Cat.No: T1831

Synonym: SR1

Target: AhR, Aryl Hydrocarbon Receptor

Cat.No: T21704

Synonym: 5F-203,NSC-703786

Target: Others

Cat.No: T13276

Synonym: 4-(3-氯苯基)-N-[4-(三氟甲基)苯基]嘧啶-2-胺

Target: Aryl Hydrocarbon Receptor

Cat.No: T2623

Synonym: PD 98059

Target: ERK, Aryl Hydrocarbon Receptor, MEK, Autophagy

Cat.No: T4644

Synonym: GSK2894512,Benvitimod,苯烯莫德,WBI 1001

Target: AhR, Aryl Hydrocarbon Receptor

Carbidopa monohydrate

Cat.No: T2148

Synonym: Carbidopa Hydrate,S(-)-Carbidopa,卡比多巴水合物

Target: Decarboxylase, Aryl Hydrocarbon Receptor

Benzyl butyl phthalate

Cat.No: T0640

Synonym: BBP,邻苯二甲酸丁苄酯,1,2-benzenedicarboxylic acid,butyl phenylmethyl ester,Butyl benzyl phthalate

Target: Others, Aryl Hydrocarbon Receptor

Pifithrin-α hydrobromide

Cat.No: T2707

Synonym: Pifithrin hydrobromide,Pifithrin-α (PFTα) HBr,Pifithrin-α,PFTα,PFTα hydrobromide

Target: Ferroptosis, Aryl Hydrocarbon Receptor, p53

Cat.No: T8980

Target: Aryl Hydrocarbon Receptor

AHR antagonist 2

Cat.No: T10269

Target: Aryl Hydrocarbon Receptor

Cat.No: T5541

Synonym: 1-[2-(4-Chloro-phenyl)-vinyl]-3,5-diMeth,PDM 11

Target: AhR

Cat.No: T10325

Target: Chk

Pifithrin-β hydrobromide

Cat.No: T3637

Synonym: Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide)

Target: Ferroptosis, p53

Cat.No: T10526

Target: Others

Benzyl 2-naphthyl ether

Cat.No: T20307

Synonym: AI3 00945,AI300945,AI3-00945

Cat.No: T24960

Synonym: 10ClBBQ

AHR-activator-1023

Cat.No: T23686

Synonym: Branching Morphogenesis Modulator 1023,Cpd 1023,Compound 1023,BMM 1023

Cat.No: T25235

Synonym: CHD5

AFP464 free base

Cat.No: T10258

Synonym: NSC710464 free base

Target: HIF

6,2',4'-Trimethoxyflavone

Cat.No: T22528

Target: Others

Cat.No: T16082

Synonym: YH439

Target: Others

AHR antagonist 4

Cat.No: T10271

Target: Others

AHR antagonist 5

Cat.No: T10272

Target: Others

Cat.No: T71938

Cat.No: T22725

Target: Others

StemRegenin 1 (hydrochloride)

Cat.No: T23400

Synonym: StemRegenin 1 (hydrochloride) (1227633-49-9 free base)

Target: Others

AhR modulator-1

Cat.No: T10273

Target: Others

Cat.No: T70257

L-Kynurenine sulfate

Cat.No: T72430

Cat.No: T61244

AHR antagonist 5 hemimaleate

Cat.No: T63389

Cat.No: T60539

Cat.No: T79283

Cat.No: T79436

Target: Aryl Hydrocarbon Receptor

Cat.No: T78716

Cat.No: T72056

1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin

Cat.No: T83826

Synonym: 1,2,3,6,7,8-HxCDD,PCDD 67

Indoxyl Sulfate-d5 potassium salt

Cat.No: T70313

Cat. No.	Product Name	Target	Signaling Pathways
TN1451	Brevifolincarboxylic acid	AhR; Aryl Hydrocarbon Receptor; Glucosidase	Immunology/Inflammation; Metabolism
	Brevifolincarboxylic acid 是从头状蓼中分离得到的一种天然产物，抑制芳烃受体(AhR)。它是一种 α-葡萄糖苷酶抑制剂，IC50 为 323.46 μM。
T6795	Carbidopa 卡比多巴,(S)-(-)-Carbidopa,Lodosyn	Decarboxylase; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism; Others
	Carbidopa (Lodosyn) 是一种选择性芳香烃受体(AhR)调节剂，是外周型脱羧酶抑制剂，抑制胰腺癌细胞和肿瘤生长，可用于帕金森病的研究。
T4928	L-Kynurenine L-犬尿氨酸,(S)-Kynurenine	AhR; Aryl Hydrocarbon Receptor; Endogenous Metabolite	Immunology/Inflammation; Metabolism
	L-Kynurenine ((S)-Kynurenine) 是L-色氨酸的代谢物，是芳香烃受体激动剂，可抑制同种异体 T 细胞增殖并增加恶性 U87 神经胶质瘤细胞侵入胶原基质。
T0878	Diosmin Venosmine,Diosmil,Barosmin,地奥司明,地奥司明（7-芸香糖甙）	Aryl Hydrocarbon Receptor; Norepinephrine	Immunology/Inflammation; Neuroscience
	Diosmin (Venosmine) 是在各种柑橘类水果中发现的类黄酮，也是芳烃受体激动剂，有增强血管壁的作用。
TN2883	3',4'-Dimethoxyflavone	Others; PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair; Others
	3',4'-Dimethoxyflavone 是类黄酮化合物的参考标准，类黄酮化合物具有多种药用活性。
T4939	Indole-3-pyruvic acid 3-(3-吲哚基)-2-氧代丙酸,3-(3-Indolyl)-2-oxopropanoic acid	Others	Others
	Indole-3-pyruvic acid (3-(3-Indolyl)-2-oxopropanoic acid) 是一种参与Indole-3-acetic acid 生物合成的化合物，Indole-3-acetic acid 是一种植物激素，在调节生长和对环境变化的反应中起重要作用。
T5281	Skatole 粪臭素,Scatole,3-Methylindole,3-Methylindole,3-甲基吲哚,3-Methyl-1H-indole,beta-Methylindole	AhR; p38 MAPK; Aryl Hydrocarbon Receptor; Endogenous Metabolite; Antibacterial; Autophagy; Antifungal	Autophagy; Immunology/Inflammation; MAPK; Metabolism; Microbiology/Virology
	Skatole (3-Methyl-1H-indole) 是由肠道菌群产生的，通过激活芳基烃受体和 p38调节肠上皮细胞功能。
T2947	Indole-3-carbinol 吲哚-3-甲醇,I3C,3-Indolemethanol,3-吲哚甲醇,Indole-3-Methanol	E1/E2/E3 Enzyme; NF-κB; Aryl Hydrocarbon Receptor; Endogenous Metabolite; p53	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; Ubiquitination
	Indole-3-carbinol (I3C) 是樟子松中的一种天然产物，是可口服的硫代葡萄糖苷葡糖苷酶裂解产物。它是芳烃受体 (AhR) 的激动剂，可抑制 NF-κB 和 IκBα 激酶活化。
TN6694	5,6-Benzoflavone β-Naphthoflavone,beta-NF	Antioxidant	oxidation-reduction
	5,6-Benzoflavone (β-Naphthoflavone) 是芳烃受体的外源配体，可破坏人肝癌 HepG2 细胞中的锌稳态。5,6-Benzoflavone (β-Naphthoflavone) 具有抗炎和抗氧化活性，抑制通过 AKT/Nrf-2/HO-1-NF-kappaB 信号转导轴，抑制 LPS 诱导的炎症，抑制TNF-α诱导的ICAM-1和VCAM-1表达，可用于研究神经退行性疾病。
T4938	Potassium 1H-indol-3-yl sulfate 硫酸吲哚钾盐,Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate	AhR; Endogenous Metabolite	Immunology/Inflammation; Metabolism
	Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) 是人芳烃受体(AhR)的激动剂。芳烃受体(AhR)最近被发现是免疫炎症条件的病理生理调节剂，Potassium 1H-indol-3-yl sulfate 已被证明是AhR的配体。Potassium 1H-indol-3-yl sulfate 也是膳食蛋白质中色氨酸的代谢物。色氨酸被肠道细菌代谢为吲哚，吲哚被吸收到血液中，然后在肝脏中进一步代谢为硫酸吲哚，通常通过尿液排出体外。在肾功能受损的慢性肾病患者中，Potassium 1H-indol-3-yl sulfate 可作为尿毒症毒素在血清中积累，诱导氧化应激并加速疾病进展。250 μM Potassium 1H-indol-3-yl sulfate 可诱导NF-Κb活化，促进大鼠近端小管细胞TGF-β1和Smad3的表达，与促纤维化活性相关。
TN6366	Lupinalbin A 鲁冰花
	Lupinalbin A as the most potent estrogen receptor α- and aryl hydrocarbon receptor agonist in Eriosema laurentii de Wild. (Leguminosae). It exerts anti-inflammatory effects via the inhibition of pro-inflammatory cytokines and blocking of IFN-β/STAT1 pathw
T75433	Norisoboldine hydrochloride
	Norisoboldine hydrochloride是一种口服活性天然芳基烃受体(AhR)激动剂，作为林参中的主要异喹啉类生物碱，适用于类风湿性关节炎和溃疡性结肠炎的研究。
T73402	Flavipin
	Flavipin 是一种芳香烃受体(Ahr)激动剂，可诱导小鼠 CD4+T 细胞和 CD11b+巨噬细胞表达 Ahr 下游基因。Flavipin 抑制 Arid5a 在 Il23a3'UTR 上的稳定功能，这是一种新发现的靶 mRNA。Flavipin 具有清除 DPPH 自由基的能力，IC50值为7.2 μM，对α-葡萄糖苷酶具有较强的抑制作用，IC50值为 33.8 μM。

天然产物

Brevifolincarboxylic acid

Cat.No: TN1451

Target: AhR, Aryl Hydrocarbon Receptor, Glucosidase

Cat.No: T6795

Synonym: 卡比多巴,(S)-(-)-Carbidopa,Lodosyn

Target: Decarboxylase, Aryl Hydrocarbon Receptor

Cat.No: T4928

Synonym: L-犬尿氨酸,(S)-Kynurenine

Target: AhR, Aryl Hydrocarbon Receptor, Endogenous Metabolite

Cat.No: T0878

Synonym: Venosmine,Diosmil,Barosmin,地奥司明,地奥司明（7-芸香糖甙）

Target: Aryl Hydrocarbon Receptor, Norepinephrine

3',4'-Dimethoxyflavone

Cat.No: TN2883

Target: Others, PARP

Indole-3-pyruvic acid

Cat.No: T4939

Synonym: 3-(3-吲哚基)-2-氧代丙酸,3-(3-Indolyl)-2-oxopropanoic acid

Target: Others

Cat.No: T5281

Synonym: 粪臭素,Scatole,3-Methylindole,3-Methylindole,3-甲基吲哚,3-Methyl-1H-indole,beta-Methylindole

Target: AhR, p38 MAPK, Aryl Hydrocarbon Receptor, Endogenous Metabolite, Antibacterial, Autophagy, Antifungal

Indole-3-carbinol

Cat.No: T2947

Synonym: 吲哚-3-甲醇,I3C,3-Indolemethanol,3-吲哚甲醇,Indole-3-Methanol

Target: E1/E2/E3 Enzyme, NF-κB, Aryl Hydrocarbon Receptor, Endogenous Metabolite, p53

5,6-Benzoflavone

Cat.No: TN6694

Synonym: β-Naphthoflavone,beta-NF

Target: Antioxidant

Potassium 1H-indol-3-yl sulfate

Cat.No: T4938

Synonym: 硫酸吲哚钾盐,Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate

Target: AhR, Endogenous Metabolite

Cat.No: TN6366

Synonym: 鲁冰花

Norisoboldine hydrochloride

Cat.No: T75433

Cat.No: T73402

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